| Identification | More | [Name]
BOC-PHE-ONP | [CAS]
7535-56-0 | [Synonyms]
BOC-PHE-ONP
Boc-L-Phe-ONp
BOC-PHENYLALANINE-ONP
BOC-PHE-ONP USP/EP/BP
Boc-Phe-(4-Nitrophenyl)OH
(Tert-Butoxy)Carbonyl Phe-ONp
Boc-L-phenylanine-4-nitropheny ester
BOC-L-PHENYLALANINE 4-NITROPHENYL ESTER
BOC-L-PHENYLALANINE P-NITROPHENYL ESTER
N-Boc-L-Phenylalanine 4-nitrophenyl ester
Boc-l-phenylalanine 4-nitrophenyl ester, 98%+
Boc-L-phenylalanine 4-nitrophenyl ester≥ 99% (HPLC)
N-(tert-butoxycarbonyl)-L-phenylalanine-4-nitrophenyl
4-Nitrophenyl (tert-butoxycarbonyl)-L-phenylalaninate
N-TERT-BUTOXYCARBONYL-L-PHENYLALANINE-P-NITROPHENYL ESTER
N-tert-Butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester
4-nitrophenyl N-(tert-butoxycarbonyl)-3-phenyl-L-alaninate
n-alpha-t-boc-l-phenylalanine-p-nitrophenylestercrystalline
N-alpha-t-boc-L-phenylalanine-p-nitrophenylester,crystalline
N-(tert-Butyloxycarbonyl)-L-phenylalanine p-nitrophenyl ester
N-(tert-Butyloxycarbonyl)-L-phenylalanine 4-nitrophenyl ester
N-alpha-t-Butyloxycarbonyl-L-phenylalanine p-nitrophenyl ester
(S)-4-Nitrophenyl2-((tert-butoxycarbonyl)amino)-3-phenylpropanoate
N-[(1,1-Dimethylethoxy)Carbonyl]-L-Phenylalanine 4-Nitrophenyl Ester
4-nitrophenyl (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoate
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenyl ester
(4-nitrophenyl)(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoate | [EINECS(EC#)]
231-404-7 | [Molecular Formula]
C20H22N2O6 | [MDL Number]
MFCD00042811 | [Molecular Weight]
386.4 | [MOL File]
7535-56-0.mol |
| Hazard Information | Back Directory | [Uses]
4-Nitrophenyl (tert-butoxycarbonyl)-L-phenylalaninate is a phenylalanine derivative[1]. | [Synthesis]
The general procedure for the synthesis of Boc-L-aniline-4-nitrophenyl ester from 4-nitrophenol and Boc-L-phenylalanine is as follows: dissolve N-tert-butoxycarbonyl-L-phenylalanine (50 g) in dichloromethane (800 ml), stirring until completely dissolved. P-nitrophenol (39 g), 4-dimethylaminopyridine (DMAP, 3 g) and dicyclohexylcarbodiimide (DCC, 39 g) were added and the reaction was carried out for 5 hours at about 20°C. After completion of the reaction, the reaction mixture was filtered and the filtrate was evaporated. Ethanol was added to the residue and heated until complete dissolution, then slowly cooled to 20-30°C to allow the solid to precipitate gradually. Water (50 ml) was added and the mixture was cooled to 0°C and crystallized for 1 hour. The solid was collected by filtration to afford the target product Boc-L-aniline-4-nitrophenyl ester (62 g, 86.5% yield, 93% purity). | [References]
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-855. DOI:10.1080/10408398.2012.708368 |
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