| Identification | Back Directory | [Name]
P1,P5-DI(ADENOSINE-5'-)PENTAPHOSPHATE, TRILITHIUM SALT | [CAS]
75522-97-3 | [Synonyms]
AP5A
AP5A, 3LI
AP5A, LI3
A(5′)P5(5′)A trilithium salt
Diadenosine pentaphosphate (trilithium)
P1,P5-DI(ADENOSINE-5'-PENTAPHOSPHATE), TRILITHIUM
P1,P5-DI(ADENOSINE-5'-)PENTAPHOSPHATE, TRILITHIUM SALT
P1,P5-DI(ADENOSINE-5'-)PENTAPHOSPHATE, TRILITHIUM SALT
Diadenosine pentaphosphate （as trilithium tetrahydrate）
P1,P5-Di(adenosine-5') pentaphosphate trilithium salt >=95%, powder
adenosine5’-(hexahydrogenpentaphosphate),5’.fwdarw.5’-esterwithadenosine,
Adenosine 5'-(hexahydrogen pentaphosphate), 5'<< trilithium adenosine, with>
Adenosine 5-(hexahydrogen pentaphosphate), P?5-ester with adenosine, trilithium salt
Adenosine 5'-(hexahydrogen pentaphosphate), 5'->5'-ester with adenosine, trilithium salt | [EINECS(EC#)]
278-237-6 | [Molecular Formula]
C20H26Li3N10O22P5 | [MDL Number]
MFCD00044936 | [MOL File]
75522-97-3.mol | [Molecular Weight]
934.17 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble50mg/mL | [form ]
powder | [color ]
white to off-white | [biological source]
synthetic (organic) | [Water Solubility ]
H2O: 50mg/mL |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt has been used as a adenylate kinase inhibitor and as a component of pre-AMPPNP rigor solution for treating muscle fibres. | [Biochem/physiol Actions]
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor. |
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