ChemicalBook--->CAS DataBase List--->75790-53-3

75790-53-3

75790-53-3 Structure

75790-53-3 Structure
IdentificationBack Directory
[Name]

H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH
[CAS]

75790-53-3
[Synonyms]

Ph-8p
YGGFLRRI
dynorphin(1-8
DYNORPHIN A (1-8)
GFL PEPTIDE STANDARD
Dynorphin A(1-8)【rat】
Dynorphin A(1-8)【human】
DYNORPHIN A (1-8), PORCINE
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE
DYNORPHIN A PORCINE FRAGMENT 1-8
Dynorphin A (1-8), porcine,YGGFLRRI
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-OH
8-L-Isoleucine-1-8-dynorphin B (swine)
1-8-Dynorphin B (swine), 8-L-isoleucine-
dynorphin A fragment 1-8 porcine*sequence
L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-L-Arg-L-Ile-OH
L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-L-Arg-L-Pro-OH
DYNORPHIN A (1-8) SYNTHETIC >97% OPIOID AGONIST
Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginyl-arginyl-isoleucine
alpha-Neoendorphin, 7-L-arginine-8-L-isoleucine-9-de-L-proline-10-de-L-lysine-
Dynorphin A (1-8) acetate salt H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-OH acetate salt
L-Isoleucine, N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-
[Molecular Formula]

C46H72N14O10
[MDL Number]

MFCD00076357
[MOL File]

75790-53-3.mol
[Molecular Weight]

981.17
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

3.38±0.10(Predicted)
[color ]

White to off-white
[Sequence]

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].
[IC 50]

κ Opioid Receptor/KOR; Human Endogenous Metabolite
[References]

[1] Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627. DOI:10.1016/0196-9781(95)00013-a
[2] Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871. DOI:10.1016/0024-3205(89)90586-9
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