| Identification | Back Directory | [Name]
Raseglurant | [CAS]
757950-09-7 | [Synonyms]
Raseglurant
Raseglurant/ADX-10059
2-((3-Fluorophenyl)ethynyl)-4,6-dimethylpyridin-3-amine
2-(3-Fluoro-phenylethynyl)-4,6-dimethyl-pyridin-3-ylamine
2-[2-(3-fluorophenyl)ethynyl]-4,6-dimethyl-3-Pyridinamine
3-Pyridinamine, 2-[2-(3-fluorophenyl)ethynyl]-4,6-dimethyl- | [Molecular Formula]
C15H13FN2 | [MDL Number]
MFCD18785292 | [MOL File]
757950-09-7.mol | [Molecular Weight]
240.28 |
| Hazard Information | Back Directory | [Uses]
Raseglurant (ADX-10059) is a mGlu5 receptor negative allosteric modulator. Raseglurant is effective against migraine. Raseglurant reduces the Haloperidol (HY-14538)-induced catalepsy in mice[1][2]. | [References]
[1] Romero-Fernandez W, et al. The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for Parkinson's Disease. Mol Neurobiol. 2022 Oct;59(10):5955-5969. DOI:10.1007/s12035-022-02946-9
[2] Font J, et al. Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. Elife. 2018 Jan 8;7:e34752. DOI:10.7554/eLife.34752 |
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