| Identification | Back Directory | [Name]
Mal-PEG1-acid | [CAS]
760952-64-5 | [Synonyms]
Mal-PEG1-acid
Mal-PEG1-CH2CH2COOH
3-[2-(2,5-Dioxo-2,5-dihydro-1h-pyrrol-1-yl)ethoxy]propanoic acid | [Molecular Formula]
C9H11NO5 | [MDL Number]
MFCD24497443 | [MOL File]
760952-64-5.mol | [Molecular Weight]
213.19 |
| Chemical Properties | Back Directory | [Boiling point ]
419.4±30.0 °C(Predicted) | [density ]
1.383±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [form ]
Solid | [pka]
4.27±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C9H11NO5/c11-7-1-2-8(12)10(7)4-6-15-5-3-9(13)14/h1-2H,3-6H2,(H,13,14) | [InChIKey]
YTZFUAXOTCJZHP-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CCOCCN1C(=O)C=CC1=O |
| Hazard Information | Back Directory | [Description]
Mal-PEG1-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Biological Activity]
Mal-PEG1-acid is a non-cleavable ADC linker containing 1 unit PEG, which can be used to synthesize antibody drug conjugates (ADC),it is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules. | [in vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
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