| Identification | Back Directory | [Name]
Mal-?PEG4-?propargyl | [CAS]
1262681-30-0 | [Synonyms]
Propargyl-PEG4-Mal
Mal-?PEG4-?propargyl | [Molecular Formula]
C15H21NO6 | [MDL Number]
MFCD29041878 | [MOL File]
1262681-30-0.mol | [Molecular Weight]
311.33 |
| Chemical Properties | Back Directory | [Boiling point ]
432.0±40.0 °C(Predicted) | [density ]
1.190±0.06 g/cm3(Predicted) | [solubility ]
good in water, DMF, DMSO | [form ]
Oil | [pka]
-2.34±0.20(Predicted) | [color ]
Colorless to light yellow | [Appearance]
yellow oil |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-Maleimide has a propargyl group and a maleimide group. The propargyl group reacts with azide compounds or biomolecules under the catalyzation of copper in Click Chemistry reactions. The maleimide group enables the formation of a covalent bond with biomolecules containing a thiol group. | [Uses]
Mal-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Mal-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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