| Identification | Back Directory | [Name]
4-(4-Pyridinyl)thiazole-2-thiol | [CAS]
77168-63-9 | [Synonyms]
4-(4-Pyridinyl)thiaz
4-(4-pyridyl)thiazole-2-thiol
4-(Pyridinyl)thiazole-2-thiol
4-(4-Pyridinyl)thiazole-2-thio
4-(4-Pyridinyl)thiazole-2-thiol
4-(pyridin-4-yl)thiazole-2-thiol
4-(4-Pyridyl)thiazole-2(3H)-thione
2-Mercapto-4-(4-Pyridinyl)thiazole
4-(4-Pyridyl)-1,3-thiazole-2-thiol
Ozefloxacin intermediate D (form 9)
PTT
4-(4-Pyridinyl)thiazole-2-thiol
4-pyridin-4-yl-3H-thiazole-2-thione
4-(4-pyridinyl)-2(3H)-Thiazolethione
4-(Pyridin-4-yl)thiazole-2(3H)-thione
4-(pyridin-4-yl)-1,3-thiazole-2-thiol
2(3H)-Thiazolethione,4-(4-pyridinyl)-
2-mercapto-4-(pyridine-4-yL) tniazoLe
4-pyridin-4-yl-3H-1,3-thiazole-2-thione
2(3H)-Thiazolethione,4-(4-pyridinyl)-EINECS
Sodium 1-(2-hydroxyethyl)-1H-tetrazol-5-ylthiolate，4-(4-Pyridinyl)thiazole-2-thiol | [EINECS(EC#)]
616-441-2 | [Molecular Formula]
C8H6N2S2 | [MDL Number]
MFCD11506654 | [MOL File]
77168-63-9.mol | [Molecular Weight]
194.28 |
| Chemical Properties | Back Directory | [Boiling point ]
364.8±52.0 °C(Predicted) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
7.01±0.40(Predicted) | [Appearance]
Yellow to brown Solid | [InChI]
InChI=1S/C8H6N2S2/c11-8-10-7(5-12-8)6-1-3-9-4-2-6/h1-5H,(H,10,11) | [InChIKey]
LEQNUYXXLYRUNY-UHFFFAOYSA-N | [SMILES]
S1C=C(C2C=CN=CC=2)NC1=S |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow powder | [Uses]
4-(4-Pyridinyl)thiazole-2-thiol is a reactant used to synthesize novel thiazolidine derivatives and azetidinone derivatives, which possess antiproliferative activity and inhibitory activity against the proliferation of the MCF-7 breast cancer cell line. | [Synthesis]
The general procedure for the synthesis of 2-mercapto-4-(4-pyridinyl)thiazole from 2-bromo-1-(pyridin-4-yl)ethanone and ammonium dithiocarbamate was as follows: to 1000 ml of water, 60 g of 4-acetylpyridine was added, the temperature was maintained at 10-15 °C, followed by the slow addition of 101 g of hydrobromic acid. Gradually 87.9 g of bromine was added dropwise at the same temperature and the reaction was kept for 1 hour after the dropwise addition. The reaction system was then warmed up to 30-35 °C and the reaction was continued for 4 h. The progress of the reaction was monitored by HPLC until the feedstock was completely consumed. Upon completion of the reaction, the reaction solution was cooled to 0 °C, 66 g of ammonium dithiocarbamate was added and the reaction was kept at 0 °C for 1 hour. After that, the reaction system was slowly warmed up to 20-25°C and the reaction was continued for 4 hours. At the end of the reaction, the solid was collected by filtration to give 81.7 g of crude 2-mercapto-4-(pyridin-4-yl)thiazole. The crude product was refluxed in water for 2 h. After cooling and filtration, 80.2 g of purified 2-mercapto-4-(pyridin-4-yl)thiazole was obtained in 82.6% yield, and the product was a light yellow solid with 99.7% HPLC purity. | [References]
[1] Patent: CN104031040, 2016, B. Location in patent: Paragraph 0023; 0024 |
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