| Identification | Back Directory | [Name]
IMegliMin (hydrochloride) | [CAS]
775351-61-6 | [Synonyms]
EMD 387008 hydrochloride
IMegliMin (hydrochloride)
(4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine
(6R)-1,6-Dihydro-N2,N2,6-trimethyl-1,3,5-triazine-2,4-diamine hydrochloride
1,3,5-Triazine-2,4-diamine, 1,6-dihydro-N,N,6-trimethyl-, hydrochloride,(+)- | [Molecular Formula]
C6H14ClN5 | [MDL Number]
MFCD28167741 | [MOL File]
775351-61-6.mol | [Molecular Weight]
191.662 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
≥29.9 mg/mL in DMSO; ≥50.3 mg/mL in EtOH; ≥62.7 mg/mL in H2O | [form ]
solid | [color ]
White to off-white | [InChI]
1S/C6H13N5.ClH/c1-4-8-5(7)10-6(9-4)11(2)3;/h4H,1-3H3,(H3,7,8,9,10);1H/t4-;/m1./s1 | [InChIKey]
UXHLCYMTNMEXKZ-PGMHMLKASA-N | [SMILES]
Cl.N1[C@@H](N=C(N=C1N(C)C)N)C |
| Hazard Information | Back Directory | [Uses]
R-Imeglimin-D3 Hydrochloride is a labelled salt analog of Imeglimin (CAS# 775351-65-0), which is a novel oral antidiabetic drug for treatment of type 2 diabetes. | [in vivo]
Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance[1]. | Animal Model: | Male C57BL/6JOlaHsd mice (4 weeks old)[1] | | Dosage: | 200 mg/kg | | Administration: | Oral gavage; b.i.d.; 6 weeks | | Result: | A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment. |
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