| Identification | Back Directory | [Name]
AI 77B | [CAS]
77674-99-8 | [Synonyms]
AI 77B
(3S,4S,5S)-3-Amino-4,5-dihydroxy-6-oxo-6-[[(S)-1-[(S)-3,4-dihydro-8-hydroxy-1-oxo-1H-2-benzopyran-3-yl]-3-methylbutyl]amino]hexanoic acid
(3S,4S,5S)-3-Amino-4,5-dihydroxy-6-oxo-6-[[(1S)-1-[(3S)-1-oxo-8-hydroxy-3,4-dihydro-1H-2-benzopyran-3-yl]-3-methylbutyl]amino]hexanoic acid | [Molecular Formula]
C20H28N2O8 | [MDL Number]
MFCD01723189 | [MOL File]
77674-99-8.mol | [Molecular Weight]
424.44 |
| Chemical Properties | Back Directory | [Melting point ]
137-138 °C | [Boiling point ]
830.3±65.0 °C(Predicted) | [density ]
1.381±0.06 g/cm3(Predicted) | [solubility ]
DMSO: soluble
Methanol: soluble | [pka]
3.48±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
AI 77B is a pseudopeptide microbial agent with gastroprotective action. | [Uses]
Amicoumacin B can be produced by actinomycete, strain 04-5195T.. Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP-2). Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 μg/mL). Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC[1][2]. | [References]
[1] Shi WP, et al. Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum. Nat Prod Res. 2021 Dec;35(23):5508-5512. DOI:10.1080/14786419.2020.1788554
[2] Sun W, et al. Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomycete. Int J Syst Evol Microbiol. 2009 Feb;59(Pt 2):417-20. DOI:10.1099/ijs.0.002899-0 |
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