| Identification | Back Directory | [Name]
7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID | [CAS]
779-27-1 | [Synonyms]
RARECHEM AL BO 2319
OTAVA-BB BB7015592710
3-CARBOXY-7-HYDROXYCOUMARIN
UMBELLIFERONE-3-CARBOXYLIC ACID
7-HYDROXYCOUMARIM-3-CARBOXYLIC ACID
7-Hydroxycoumarin-3-carboxylicAcid>
7-Hydroxycoumarin-3-carboxylic acid ,98%
7-hydroxy-2-oxochromene-3-carboxylic acid
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID
7-Hydroxycoumarin-3-carboxylic acid *CAS 779-27-1*
2H-1-Benzopyran-3-carboxylic acid, 7-hydroxy-2-oxo-
7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID, FOR FLUORESCENCE
7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID ISO 9001：2015 REACH
7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID FOR FLUORESCENCE 98+%
7-HydroxycouMarin-3-carboxylic acid [uMbelliferone-3-carboxylic acid] | [EINECS(EC#)]
1415-596-9 | [Molecular Formula]
C10H6O5 | [MDL Number]
MFCD00017491 | [MOL File]
779-27-1.mol | [Molecular Weight]
206.15 |
| Chemical Properties | Back Directory | [Melting point ]
261 °C(lit.)
| [Boiling point ]
474.8±45.0 °C(Predicted) | [density ]
1.639±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF: soluble
| [form ]
powder to crystal | [pka]
7.04 ± 0.02, temperature: 23 °C | [color ]
Yellow solid;Orange solid;
Off-white powder | [λmax]
386 nm (Buffer pH 10.0); 339 nm
(Buffer pH 4.0) | [BRN ]
384141 | [Biological Applications]
Chemical dosimeter
for radiation therapy; detecting bacteria;
detecting/sensing hydroxyl radicals; studying
nucleic acids; as a substrate for measuring
carboxylesterases activity, cellulases activity,
β-galactosidases activity, glycosidases activity,
glycosyltransferases activity, hydrolases activity,
4-hydroxycinnamate decarboxylases activity,
β-lactamases activity, phosphatases activity,
sulfatases activity; treating cancer/antitumor
activity | [Major Application]
Carbon-dioxide sensor;
chemical sensors based on non-linear optics;
monitoring of cationic photopolymerization processes;
nanomaterials | [InChI]
InChI=1S/C10H6O5/c11-6-2-1-5-3-7(9(12)13)10(14)15-8(5)4-6/h1-4,11H,(H,12,13) | [InChIKey]
LKLWLDOUZJEHDY-UHFFFAOYSA-N | [SMILES]
C1(=O)OC2=CC(O)=CC=C2C=C1C(O)=O |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [F ]
8 | [HS Code ]
29329990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
Suitable as pH-indicator. | [Synthesis]
General procedure for the synthesis of 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylic acid from ethyl 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylate: ethyl 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylate (2.00 g, 8.55 mmol) was dissolved in water (20 ml) at 90 °C and concentrated hydrochloric acid (6 ml) was added slowly. The reaction mixture was refluxed for 8 hours. After the reaction was completed, the reaction solution was cooled to room temperature, the precipitate was collected by filtration and washed with cold water to obtain 7-hydroxy-2-oxo-2H-benzopyran-3-carboxylic acid (1.32 g, 6.41 mmol) as a light red solid in 75% yield. | [References]
[1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986, vol. 25, p. 638 - 639
[2] Food Chemistry, 2012, vol. 135, # 4, p. 2872 - 2878
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 502 - 506
[4] Chemical Communications, 2017, vol. 53, # 11, p. 1813 - 1816
[5] Patent: CN106279125, 2017, A. Location in patent: Paragraph 0041; 0042 |
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