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780822-35-7

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780822-35-7 Structure

780822-35-7 Structure

Identification	Back Directory
[Name] N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide
[CAS] 780822-35-7
[Synonyms] N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-yl]-2-oxo-1,3-dihydrobenzimidazole-5-sulfonamide 1H-Benzimidazole-5-sulfonamide, 2,3-dihydro-N-[4-hydroxy-3-(1H-1,2,4-triazol-5-ylthio)-1-naphthalenyl]-2-oxo-
[Molecular Formula] C19H14N6O4S2
[MOL File] 780822-35-7.mol
[Molecular Weight] 454.48

Chemical Properties	Back Directory
[density ] 1.78±0.1 g/cm3(Predicted)
[pka] 6.82±0.50(Predicted)

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[Uses] hsa62 is a dual inhibitor for SIRT1 and SIRT2, with IC50 of 1.3 and 5.5 μM, respectively[1].
[IC 50] SIRT1: 1.3 μM (IC₅₀); SIRT2: 5.5 μM (IC₅₀); SIRT3: 43.6 μM (IC₅₀)
[References] [1] Cai H, et al., Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790. DOI:10.1021/acs.jcim.3c00556

780822-35-7 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

Company Name:	OTAVA chemicals
Tel:	416 305 9979 (Canada)
Website:	www.otavachemicals.com

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