| Identification | More | [Name]
9-Fluorenone-2-carboxylic acid | [CAS]
784-50-9 | [Synonyms]
9-FLUORENONE-2-CARBOXYLIC ACID
9-OXO-2-FLUORENECARBOXYLIC ACID
9-OXO-9H-FLUORENE-2-CARBOXYLIC ACID
LABOTEST-BB LT00153934
9H-Fluorene-2-carboxylic acid, 9-oxo-
Fluorenone-2-carboxylic acid
Fluorenone-2-carboxylicacid
9-oxofluoren-2-carboxylic acid
9-Oxofluorene-2-carboxylic acid
9-Fluorenone-2-CarboxylicAcid99%
9-Fluorenone-2-Carboxylic Acid 99%
9-Oxo-2-fluorenecarboxyic Acid
9-FLUOROENONE-2-CARBOXYLIC ACID | [EINECS(EC#)]
212-317-3 | [Molecular Formula]
C14H8O3 | [MDL Number]
MFCD00001156 | [Molecular Weight]
224.21 | [MOL File]
784-50-9.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow fine powder | [Melting point ]
>300 °C (lit.) | [Boiling point ]
325.61°C (rough estimate) | [density ]
1.2337 (rough estimate) | [refractive index ]
1.5400 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Fine Powder | [pka]
3.85±0.20(Predicted) | [color ]
Yellow | [InChI]
1S/C14H8O3/c15-13-11-4-2-1-3-9(11)10-6-5-8(14(16)17)7-12(10)13/h1-7H,(H,16,17) | [InChIKey]
BJCTXUUKONLPPK-UHFFFAOYSA-N | [SMILES]
OC(=O)c1ccc2-c3ccccc3C(=O)c2c1 | [CAS DataBase Reference]
784-50-9(CAS DataBase Reference) | [NIST Chemistry Reference]
9-Fluorenone-2-carboxylic acid(784-50-9) |
| Safety Data | Back Directory | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29183000 | [Storage Class]
13 - Non Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
yellow fine powder | [Uses]
9-Fluorenone-2-carboxylic Acid (cas# 784-50-9) is a compound useful in organic synthesis. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 70, p. 3958, 1948 DOI: 10.1021/ja01191a530
Organic Syntheses, Coll. Vol. 3, p. 420, 1955 | [Synthesis]
General procedure for the synthesis of 9-fluorenone-2-carboxylic acid from the compound (CAS: 3096-44-4): potassium hydroxide (1.6 g, 29.4 mmol) was added to a mixture of methanol (7 mL) and water (7 mL) containing compound 12 (200 mg, 0.98 mmol), and the reaction mixture was stirred for 6 hours at 110 °C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The pH was adjusted to 3 with 1 N hydrochloric acid and the mixture was extracted with ethyl acetate (30 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford the target product 9-fluorenone-2-carboxylic acid (200 mg, 91% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δ 13.30 (s, 1H), 8.19 (d, J = 7.6 Hz, 1H), 8.03 (s, 1H), 7.97-9.89 ( m, 2H), 7.72-7.64 (m, 2H), 7.50-7.44 (m, 1H). | [References]
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 22, p. 5861 - 5872
[2] Patent: CN104557862, 2017, B. Location in patent: Paragraph 0102-0104; 0109-0110 |
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