| Identification | Back Directory | [Name]
NSC305787 | [CAS]
785718-37-8 | [Synonyms]
NSC305787
NSC-305787,NSC305787
4-Quinolinemethanol, 6,8-dichloro-α-2-piperidinyl-2-tricyclo[3.3.1.13,7]dec-1-yl- | [Molecular Formula]
C25H30Cl2N2O | [MDL Number]
MFCD29126236 | [MOL File]
785718-37-8.mol | [Molecular Weight]
445.43 |
| Chemical Properties | Back Directory | [Boiling point ]
597.2±45.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 6 mg/mL (13.47 mM) | [form ]
Solid | [pka]
12.84±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKCΙ with an IC50 of 8.3 μM, has antitumor activity. | [in vivo]
NSC305787 (0.240 mg/kg/day, i.p.) suppresses ezrin-dependent osteosarcoma metastatic growth in mouse lung[1]. NSC305787 (240 μg/kg, i.p.) dramatically inhibits pulmonary metastasis in a transgenic mouse model of osteosarcoma (Osx-Cre+p53fl/flpRBfl/fl) and shows a more favorable pharmacokinetic profile compared with NSC668394 in the mouse model[2]. | [storage]
Store at -20°C | [References]
[1] Bulut G, et al. Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene. 2012 Jan 19;31(3):269-81. DOI:10.1038/onc.2011.245
[2] ?elik H, et al. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17;291(25):13257-70. DOI:10.1074/jbc.M116.718189 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|