| Identification | Back Directory | [Name]
2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile | [CAS]
78940-62-2 | [Synonyms]
MDL-860
MDL-860 >=98% (HPLC)
2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile
Benzonitrile, 2-(3,4-dichlorophenoxy)-5-nitro- | [Molecular Formula]
C13H6Cl2N2O3 | [MOL File]
78940-62-2.mol | [Molecular Weight]
309.1 |
| Hazard Information | Back Directory | [Uses]
MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection[1]. | [Biological Activity]
MDL-860 is a 5-nitro-2-phenoxybenzonitrile th at exerts broad-spectrum antipicornaviral activity (MIC50 from 0.1-1.5 μg/mL in HeLa cultures) by acting as an irreversible inhibitor against host phosphatidylinositol-4 kinase beta (PI4KB; PtdIns 4-kinase beta; PI4Kbeta; NPIK; PI4K92) via covalent modification of Cys646 located at the bottom of a surface pocket apart from the PI4KB active site. MCL-860 (MIC50 from 0.1-1.5 μg/mL in HeLa cultures). A pleconaril/MDL-860/oxoglaucine consecutive alternating administration (CAA)but not simultaneous daily treatmentis reported to be effective against coxsackievirus B1 infection without the development of drug resistance in newborn mice (75 mg/kg MDL-860 via s.c. every third day on the day following pleconaril and prior to oxoglaucine). | [References]
[1] Nikolova I, et al. Anti-enteroviral activity of new MDL-860 analogues: Synthesis, in vitro/in vivo studies and QSAR analysis. Bioorg Chem. 2019 Apr;85:487-497. DOI:10.1016/j.bioorg.2019.02.020 |
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Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
| Company Name: |
TargetMol
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400-821-0310 15002144251 |
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www.targetmol.cn/ |
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