| Identification | Back Directory | [Name]
ITMN 4077 | [CAS]
790305-05-4 | [Synonyms]
ITMN 4077
ITMN-4077,ITMN4077
t - butyl (2R,6S,13aS,14aR,16aS,Z) - 14a - (cyclopropylsulfonylcarbamoyl) - 2 - hydroxy - 5,16 - dioxo - 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a - hexadecahydrocyclopropa[e]pyrrolo[1,2 - a][1,4]diazacyclopentadecin - 6 - ylcarbamate
Carbamic acid, N-[(2R,6S,12Z,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-2-hydroxy-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C26H40N4O8S | [MDL Number]
MFCD30475783 | [MOL File]
790305-05-4.mol | [Molecular Weight]
568.68 |
| Chemical Properties | Back Directory | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [form ]
Solid | [pka]
4.44±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC50: 2131 nM)[1][2]. | [storage]
Store at -20°C | [References]
[1] Rajagopalan R, et al. Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behavior. Biochemistry. 2009 Mar 24;48(11):2559-68. DOI:10.1021/bi900038p
[2] Jiang Y, et al. Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease. J Med Chem. 2014 Mar 13;57(5):1753-69. DOI:10.1021/jm400164c |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
AbaChemScene
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| Tel: |
732-484-9848 |
| Website: |
www.chemscene.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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