79032-48-7

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79032-48-7 Structure

Identification	Back Directory
[Name] SNAP
[CAS] 79032-48-7
[Synonyms] SNAP SNAP(D) S-Nitroso-acetyl penicillamine S-NITROSO-N-ACETYLPENICILLAMINE N-ACETYL-3-(NITROSOTHIO)-D-VALINE S-NITRO-N-ACETYL-D,L-PENACILLAMINE N-Acetyl-S-nitroso-D-penicillaMine S-nitroso-N-acetyl-D-penicillamine S-Nitroso-N-acetyl-D-b,b-dimethylcysteine S-NITROSO-N-ACETYL-D-BETA,BETA-DIMETHYLCYSTEINE 2-acetamido-3-methyl-3-(nitrosothio)butyric acid 2-acetamido-3-methyl-3-nitrososulfanylbutanoic acid 2-acetamido-3-methyl-3-nitrososulfanyl-butanoic acid S-NITROSO-N-ACETYLPENICILLAMINE (SNAP) P OTENT VASODILATOR
[Molecular Formula] C7H12N2O4S
[MDL Number] MFCD00153852
[MOL File] 79032-48-7.mol
[Molecular Weight] 220.25

Chemical Properties	Back Directory
[Appearance] Green Crystalline Solid
[density ] 1.36±0.1 g/cm3(Predicted)
[storage temp. ] −20°C
[solubility ] H₂O: ≥2 mg/mL
[form ] powder
[pka] 3.06±0.10(Predicted)
[color ] green

Hazard Information	Back Directory
[Chemical Properties] Green Crystalline Solid
[Uses] The D-isomer of SNAP. Serves as an NO donor
[Definition] ChEBI: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.
[Biological Activity] A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t ?of 37h.
[General Description] Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t_1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
[Biochem/physiol Actions] EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
[storage] Store at -20°C

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