| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:10.0(Max Conc. mg/mL);17.86(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);17.86(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.25(Max Conc. mM) | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells when used at lipid concentrations greater than 20 μM. DMHAPC-Chol, as part of a lipoplex with DOPE , has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF. | [References]
[1] A PERCOT . A hydroxyethylated cholesterol-based cationic lipid for DNA delivery: effect of conditioning[J]. International Journal of Pharmaceutics, 2004, 278 1: Pages 143-163. DOI: 10.1016/j.ijpharm.2004.03.003
[2] WUXIAO DING . Hydroxyethylated cationic cholesterol derivatives in liposome vectors promote gene expression in the lung[J]. International Journal of Pharmaceutics, 2008, 354 1: Pages 196-203. DOI: 10.1016/j.ijpharm.2007.10.051
[3] DOMINIQUE BRIANE. Inhibition of VEGF expression in A431 and MDA-MB-231 tumour cells by cationic lipid-mediated siRNA delivery.[J]. Journal of Drug Targeting, 2012, 20 4: 347-354. DOI: 10.3109/1061186x.2012.656645 |
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