| Identification | Back Directory | [Name]
Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- | [CAS]
796079-91-9 | [Synonyms]
WAY-640674
4-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-(pyridin-3-yl)quinazoline
Quinazoline, 4-(3,4-dihydro-2(1H)-isoquinolinyl)-2-(3-pyridinyl)- | [Molecular Formula]
C22H18N4 | [MOL File]
796079-91-9.mol | [Molecular Weight]
338.41 |
| Chemical Properties | Back Directory | [Boiling point ]
490.0±45.0 °C(Predicted) | [density ]
1.250±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.21±0.59(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
GCase modulator-1 (compound 9g), a derivative of Quinazoline, is a modulator of GCase (Glucosidase) (AC50=2.23 μM)[1]. | [References]
[1] Zheng J, et al. Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase. J Med Chem. 2019 Feb 14;62(3):1218-1230. DOI:10.1021/acs.jmedchem.8b01294 |
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