ChemicalBook--->CAS DataBase List--->79640-70-3

79640-70-3

79640-70-3 Structure

79640-70-3 Structure
IdentificationBack Directory
[Name]

Methotrexate α-tert-Butyl Ester
[CAS]

79640-70-3
[Synonyms]

Methotrexate α-tert-Butyl Ester
(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
[Molecular Formula]

C24H30N8O5
[MDL Number]

MFCD32868559
[MOL File]

79640-70-3.mol
[Molecular Weight]

510.55
Chemical PropertiesBack Directory
[Melting point ]

>211°C (dec.)
[density ]

1.377±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
[form ]

Solid
[pka]

4.43±0.10(Predicted)
[color ]

Pale Yellow to Orange
Hazard InformationBack Directory
[Uses]

Methotrexate α-tert-Butyl Ester is an intermediate to the synthesis of folic acid antagonist Methotrexate (M260675) used in the study of membrane-associated folate transporters from L1210 cells.
[in vivo]

Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice[1].
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo[1].

Animal Model:Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells)[1]
Dosage:30 mg/kg
Administration:Once per week for 2 weeks
Result:Showed a significant (63%) reduction in tumor size on day 12.
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