79640-70-3
中文名称
Methotrexate α-tert-Butyl Ester
英文名称
Methotrexate α-tert-Butyl Ester
CAS
79640-70-3
分子式
C24H30N8O5
更新日期
2025/05/26 09:22:21
分子量
510.55
MOL 文件
79640-70-3.mol
基本信息
中文别名
187819 英文别名
Methotrexate α-tert-Butyl Ester(S)-5-(tert-butoxy)-4-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)-5-oxopentanoic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(1,1-dimethylethyl) ester
所属类别
医药中间体：原料药中间体物理化学性质
熔点>211°C (dec.)
密度1.377±0.06 g/cm3(Predicted)
储存条件-20°C Freezer
溶解度Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
酸度系数(pKa)4.43±0.10(Predicted)
形态Solid
颜色Pale Yellow to Orange
Methotrexate α-tert-Butyl Ester价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-133887 | Methotrexate α-tert-butyl ester | 79640-70-3 | 5 mg | 2800元 |
| 2025/05/22 | HY-133887 | Methotrexate α-tert-butyl ester | 79640-70-3 | 10 mg | 4500元 |
常见问题列表
生物活性
Methotrexate α-tert-butyl ester，经 OtBu 修饰，显著降低 HT1080 荷瘤小鼠的肿瘤生长。Methotrexate 是一种抗代谢和抗叶叶酸剂，也是一种免疫抑制剂和抗肿瘤药物。体外研究
OtBu-MTX-PVG is less HT1080 than MTX-PVG against HT1080 cells. It shows that protection of the α-carboxyl group of MTX results in reduced in vitro activity.
体内研究
Lys-MTXcleavable- (OtBu) significantly reduces tumor growth in HT1080 tumor bearing mice.
The protection of the α-carboxyl group of methotrexate may be used to improve the circulatory half-life and reduce the liver accumulation of similar MTX-conjugated dendrimers, while still retaining antitumor activity in vivo.
| Animal Model: | Female, Balb/c nu/nu, 6 weeks (bearing HT1080 cells) |
| Dosage: | 30 mg/kg |
| Administration: | Once per week for 2 weeks |
| Result: | Showed a significant (63%) reduction in tumor size on day 12. |