| Identification | More | [Name]
Tobramycin sulfate | [CAS]
79645-27-5 | [Synonyms]
TOBRAMYCIN SULFATE
TOBRAMYCIN SULFATE SALT
TOBRAMYCIN SULPHATE
4-Amino-2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol sulfate
Tobramycin sulfate | [EINECS(EC#)]
256-499-2 | [Molecular Formula]
C18H39N5O13S | [MDL Number]
MFCD00133864 | [Molecular Weight]
565.59 | [MOL File]
79645-27-5.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
T,Xn | [Risk Statements ]
R61:May cause harm to the unborn child.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [RTECS ]
WK2110000 |
| Hazard Information | Back Directory | [Description]
Tobramycin Sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis. | [Originator]
Nebcin (Lilly). | [Uses]
Tobramycin Sulfate is an antibiofilm formulations. | [Indications]
Used in the treatment of septicemia (bloodstream infection), infections of the skin, bone, lower respiratory tract, central nervous system, intra-abdominal and complicated recurrent urinary tract infections. | [Side effects]
The most common side effects of Tobramycin sulfate include:- Nephrotoxicity (Kidney Toxicity)
Tobramycin sulfate, like other aminoglycosides, can cause nephrotoxicity. This toxicity is usually reversible discontin uponuation of the drug. It is more likely to occur with prolonged use or in patients with pre-existing kidney dysfunction.- Ototoxicity (Ear Toxicity)
Ototoxicity is another common side effect, which can manifest as vestibular dysfunction or hearing loss. This toxicity is often irreversible and may be more prevalent in patients with genetic predispositions. |
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