| Identification | Back Directory | [Name]
SULFACHLOROPYRIDAZINE | [CAS]
80-32-0 | [Synonyms]
Prinz
Cosulid
Soxilyn
Sonilyn
Ba-10370
Consulid
Durasulf
NEFROSUL
Bactolin
Cluricol
Ciba 10370
Renalsulfa
Sulfarene.
Sulpirazina
AKOS B014357
Sulfachloropy
Nefrosul (TN)
Sulfaclorazina
ART-CHEM-BB B014357
TIMTEC-BB SBB001158
VetisullideNefrosul
SULFACHLORPYRIDAZINE
Sulfochlorpyridazine
SULFACHLOROPYRIDAZINE
Sulphachlorpyridazine
LABOTEST-BB LT00772309
SULPHACHLOROPYRIDAZINE
Vetisulid (Veterinary)
Sulfachlorpyridazine (USP)
Sulfachlorpyridazine (200 mg)
SulfachloropyridazineSodiumSalt
3-Chloro-6-sulfanilamidopyridazine
6-Sulfanilamido-3-chloropyridazine
6-Chloro-3-sulfanilamidopyridazine
Sulfachlorpyridazine solution,100ppm
sulfachloropyridazine Solution, 100ppm
N1-(6-Chlor-3-pyridazinyl)sulfanilamid
N1-3-chloropyridazin-6-ylsulphanilamide
SULFACHLOROPYRIDAZINE VETRANAL, 250
N’-(6-Chloro-3-pyridazinyl)sulfanilamide
N1-(6-Chloro-3-pyridazinyl)sulfanilamide
sulfachlorpyridazine sulfachloropyridazine
N(sup 1)-(6-Chloro-3-pyridazinyl)sulfanilamide
Sulfachlorpyridazine (base and/or unspecified salts)
4-AMINO-N-(6-CHLORO-3-PYRIDAZINYL)BENZENESULFONAMIDE
4-amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide
4-azanyl-N-(6-chloropyridazin-3-yl)benzenesulfonamide
benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)-
Sulfachloropyridazine,4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide | [EINECS(EC#)]
201-269-9 | [Molecular Formula]
C10H9ClN4O2S | [MDL Number]
MFCD00057371 | [MOL File]
80-32-0.mol | [Molecular Weight]
284.72 |
| Chemical Properties | Back Directory | [Melting point ]
186-187℃ | [Boiling point ]
559.7±60.0 °C(Predicted) | [density ]
1.588 | [refractive index ]
1.6300 (estimate) | [storage temp. ]
0-6°C | [solubility ]
0.5 M NaOH: soluble50mg/mL | [form ]
powder | [pka]
pKa 6.10 (Uncertain) | [color ]
off-white to light yellow | [BRN ]
261558 | [Major Application]
clinical testing | [InChI]
1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15) | [InChIKey]
XOXHILFPRYWFOD-UHFFFAOYSA-N | [SMILES]
Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 | [EPA Substance Registry System]
Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)- (80-32-0) |
| Hazard Information | Back Directory | [Uses]
Antibacterial compound. | [Definition]
ChEBI: A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. | [Originator]
Sonilyn,Mallinckrodt Inc.,US,1962 | [Manufacturing Process]
1.9 parts of 3,6-dichloropyridazine, 3.4 parts of sulfanilamide, 2.7 parts of
potassium carbonate and 1 part of sodium chloride were ground together. The
solid mixture was heated with stirring and as the dichloropyridazine and
sulfanilamide melted, the mixture became a slurry. When the bath
temperature had reached 140°C a sudden evolution of carbon dioxide
occurred which lasted about 5 minutes, after which the mixture set in fine
granules. When no more carbon dioxide was evolved, heating was stopped
and the reaction mixture was heated with sufficient water to dissolve it and
the solution allowed to cool. Unreacted sulfanilamide was collected by
filtration. Excess dichloropyridazine was removed from the filtrate by
extraction with a water immiscible organic solvent such as ether.
The basic solution was chilled and poured into one-half volume of 1:3 acetic
acid. Sufficient hydrochloric acid was added to bring the mixture to pH 4. The
crude 3-sulfanilamido-6-chloropyridazine which precipitated was purified by
solution in 6 parts of 1:100 ammonium hydroxide, charcoal treatment and
precipitation by pouring of the filtrate into dilute acetic acid. | [Brand name]
Nefrosul (3M Pharmaceuticals); Sonilyn,(Carter-Wallace); Vetisulid [Veterinary] (Fort Dodge Animal Health). | [Therapeutic Function]
Antibacterial |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H317 | [Precautionary statements ]
P280 | [Hazard Codes ]
Xi | [Risk Statements ]
43 | [Safety Statements ]
36/37 | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
2935909550 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Skin Sens. 1 |
| Questions And Answer | Back Directory | [Description]
It is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood. Specifically, due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.1 Moreover, this substance can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.2 In addition, this compound can act as an eco-friendly inhibitor for corrosion of mild steel in H2SO4 solution.3 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.4
| [Brand Name(s) in US]
Vetisulid
| [Reference]
- Stolar, M. E., Synergistic antibacterial composition US Patent 4470978 1984.
- Gerhard Lukas; Atasoy, K., Aqueous liquid formulations for control of bacterial and protozoal diseases US Patent 4423043 1983.
- Omar A. Hazazi; Ahmed Fawzy; Awad, M. I., Sulfachloropyridazine as an Eco-Friendly Inhibitor for Corrosion of Mild Steel in H2SO4 Solution Chemical Science Review and Letters 2015, 4, 67-79.
- M. Nakano; M.N. Narimatsu; Portugal, M. A. S. C., Use of sulfachloropyridazine associated to tripelennamine hydrochloride as anti-stress agent in poultry after vaccinations. Biologico 1977.
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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