| Identification | More | [Name]
6-Chloropyridazin-3-amine | [CAS]
5469-69-2 | [Synonyms]
3-AMINO-6-CHLOROPYRIDAZINE
6-CHLORO-3-PYRIDAZINYLAMINE
6-CHLOROPYRIDAZIN-3-AMINE
6-CHLOROPYRIDAZIN-3-YLAMINE
AMINO(3-)-6-CHLOROPYRIDAZINE
BUTTPARK 44\01-57
TIMTEC-BB SBB005487
6-chloro-3-pyridazinamin
6-Chloro-3-aminopyridazine
3-Amino-6-chloropyrazine
3-AMINO-6-CHLOROPYRIDAZINE,6-CHLOROPYRIDAZIN-3-AMINE
3-AMINO-6-CHLOROPYRIDAZINE 98%
6-Chloropyridazin-3-amine ,98%
6-Chloro-3-pyridazinamine | [EINECS(EC#)]
226-796-1 | [Molecular Formula]
C4H4ClN3 | [MDL Number]
MFCD00051506 | [Molecular Weight]
129.55 | [MOL File]
5469-69-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Brown Solid | [Melting point ]
210 °C | [Boiling point ]
363.2±22.0 °C(Predicted) | [density ]
1.437±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
4.06±0.10(Predicted) | [color ]
Light Brown to Brown | [Detection Methods]
HPLC,NMR | [BRN ]
110918 | [InChI]
InChI=1S/C4H4ClN3/c5-3-1-2-4(6)8-7-3/h1-2H,(H2,6,8) | [InChIKey]
DTXVKPOKPFWSFF-UHFFFAOYSA-N | [SMILES]
C1(N)=NN=C(Cl)C=C1 | [CAS DataBase Reference]
5469-69-2(CAS DataBase Reference) | [EPA Substance Registry System]
5469-69-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Solid | [Uses]
3-Amino-6-chloropyridazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Definition]
ChEBI: 3(S)-hydroxy-13-cis-eicosenoyl-CoA is a member of pyridazines. | [Synthesis]
The general procedure for the synthesis of 3-amino-6-chloropyridazine from 3,6-dichloropyridazine was as follows: 3,6-dichloropyridazine (107,500 mg, 3.36 mmol) was slowly added to 2.0 M ammonia methanol solution (NH3 in MeOH, 17 mL, 33.6 mmol). The reaction mixture was heated at 130 °C for 96 h and subsequently cooled to room temperature. After the reaction was completed, water was carefully added. The organic compounds were extracted with ethyl acetate and the combined organic phases were washed with saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford the target compound 3-amino-6-chloropyridazine (108d, 265 mg, 61% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CD3OD) δ 6.95 (d, J = 9.6 Hz, 1H), 7.34 (d, J = 9.2 Hz, 1H) and 13C NMR (100 MHz, CD3OD) δ 119.8, 131.1, 147.1, 161.5. | [References]
[1] Patent: WO2013/59587, 2013, A1. Location in patent: Page/Page column 74; 75
[2] Patent: EP2768509, 2017, B1. Location in patent: Paragraph 0237; 0238
[3] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1165 - 1173
[4] Organic and Biomolecular Chemistry, 2010, vol. 8, # 18, p. 4131 - 4136
[5] Patent: WO2007/26623, 2007, A1. Location in patent: Page/Page column 6-7 |
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