| Identification | Back Directory | [Name]
GPI 15427 | [CAS]
805242-85-7 | [Synonyms]
GPI 15427
DZRLVSOGARUEGQ-UHFFFAOYSA-N
[1]Benzopyrano[4,3,2-de]phthalazin-3(2H)-one, 10-[(4-methyl-1-piperazinyl)methyl]- | [Molecular Formula]
C20H20N4O2 | [MDL Number]
MFCD09832576 | [MOL File]
805242-85-7.mol | [Molecular Weight]
348.4 |
| Hazard Information | Back Directory | [Uses]
GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation[1]. | [References]
[1] Treatment with PARP-1 inhibitors, GPI 15427 or GPI 16539, ameliorates intestinal damage in rat models of colitis and shock |
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