| Identification | Back Directory | [Name]
MALAT1 inhibitor 5
(Malat1 inhibitor 5) | [CAS]
827327-28-6 | [Synonyms]
TC SL C5
MALAT1 inhibitor 1
MALAT1 inhibitor 5
MALAT1 inhibitor 5
(Malat1 inhibitor 5)
1H-Imidazol-2-amine, 5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl- | [Molecular Formula]
C19H21N3O2 | [MDL Number]
MFCD06011226 | [MOL File]
827327-28-6.mol | [Molecular Weight]
323.39 |
| Chemical Properties | Back Directory | [Boiling point ]
534.0±60.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (386.53 mM) | [form ]
Solid | [pka]
7.50±0.25(Predicted) | [color ]
Light yellow to khaki | [InChI]
1S/C19H21N3O2/c1-22-18(15-7-9-16(23-2)10-8-15)13-21-19(22)20-12-14-5-4-6-17(11-14)24-3/h4-11,13H,12H2,1-3H3,(H,20,21) | [InChIKey]
LCVOJBGSGIOMKF-UHFFFAOYSA-N | [SMILES]
[n]1(c(ncc1c3ccc(cc3)OC)NCc2cc(ccc2)OC)C |
| Hazard Information | Back Directory | [Uses]
MALAT1-IN-1 (compounds 5) is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting expression of nuclear enriched abundant transcript 1 (Neat1) [1]. | [Biological Activity]
MALAT1-IN-5 reduces the long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) level (by 54% in 7 days at 1 μM; MMTV-PyMT tumors organoids) via specific interaction with Malat1 triple-helical configuration of 3μ-terminal element for nuclear expression (ENE KD = 2.9 μM under physiologic ionic conditions)but not the homologous 3μ-end triple-helix of Neat1 (MENβ) lncRNA. MALAT1-IN-5 decreases MMTV-PyMT organoid branching morphogenesis (by 38% in 7 days at 1 μM) and modulates the levels of Malat1-targeted mRNAs Krt16 & Csn2. | [storage]
Store at -20°C | [References]
[1] Abulwerdi FA, et al. Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chem Biol. 2019 Feb 15;14(2):223-235. DOI:10.1021/acschembio.8b00807 |
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