| Identification | Back Directory | [Name]
4-bromo-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide | [CAS]
82973-15-7 | [Synonyms]
MAO-B-IN-30
4-bromo-N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)benzohydrazide
4-bromo-N'-[(3Z)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide
Benzoic acid, 4-bromo-, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide | [Molecular Formula]
C15H10BrN3O2 | [MDL Number]
MFCD00410846 | [MOL File]
82973-15-7.mol | [Molecular Weight]
344.16 |
| Hazard Information | Back Directory | [Uses]
MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier MAO-B inhibitor with IC50 values of 19.176, 0.082 μM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease[1]. | [IC 50]
MAO-B: 0.082 μM (IC50); MAO-A: 19.176 μM (IC50) | [References]
[1] Kumar S, Oh JM, Prabhakaran P, Awasti A, Kim H, Mathew B. Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect. Sci Rep. 2024 Jan 13;14(1):1264. DOI:10.1038/s41598-024-51728-x |
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| Company Name: |
Merck KGaA
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21-20338288 |
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www.sigmaaldrich.cn |
| Company Name: |
OTAVA chemicals
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416 305 9979 (Canada) |
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www.otavachemicals.com |
| Company Name: |
Aronis
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+79265780336 |
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www.aronis.ru |
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