| Identification | Back Directory | [Name]
YM 2447690 | [CAS]
837424-39-2 | [Synonyms]
YM 244769
YM 2447690
N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride | [Molecular Formula]
C27H24ClFN2O3 | [MOL File]
837424-39-2.mol | [Molecular Weight]
478.942 |
| Hazard Information | Back Directory | [Uses]
YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis. | [Uses]
YM 2447690 is a sodium-calcium exchanger (NCX) inhibitor used for the prevention and treatment of reperfusion arrhythmias, myocardial contracture and necrosis. This compound has neuroprotective properties. | [in vivo]
YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+ as well as Ca2+/Cr ratio[2]. | Animal Model: | Wild-type C57BL/6J mice and NCX-KO mice[2] | | Dosage: | 0.1, 0.3 and 1 mg/kg | | Administration: | Oral administration, once | | Result: | Caused a dose-dependent increase (up to approximately 200%) in urine volume and urinary excretion of electrolytes (Na+, K+ and Cl-). Natriuretic actions were equivalently observed in NCX1-KO and WT, but disappeared in NCX2-KO and double KO. |
| [storage]
Desiccate at RT |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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