| Identification | More | [Name]
4-(DIFLUOROMETHOXY)ACETOPHENONE | [CAS]
83882-67-1 | [Synonyms]
1-(4-DIFLUOROMETHOXY-PHENYL)-ETHANONE
4'-(DIFLUOROMETHOXY)ACETOPHENONE
4-(DIFLUOROMETHOXY)ACETOPHENONE
AKOS B016264
AKOS BBS-00000545
ART-CHEM-BB B016264
1-[4-(difluoromethoxy)phenyl]ethan-1-one
4'-(Difluoromethoxy)acetophenone 98%
4'-(Difluoromethoxy)acetophenone98% | [EINECS(EC#)]
281-174-7 | [Molecular Formula]
C9H8F2O2 | [MDL Number]
MFCD00042250 | [Molecular Weight]
186.16 | [MOL File]
83882-67-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
18-19°C | [Boiling point ]
70-72°C 0,5mm | [density ]
1.191±0.06 g/cm3(Predicted) | [refractive index ]
1.4930 to 1.4970 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Light orange to Yellow to Green | [λmax]
252nm(EtOH)(lit.) | [CAS DataBase Reference]
83882-67-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Hazard Note ]
Irritant | [HS Code ]
2914790090 |
| Hazard Information | Back Directory | [Chemical Reactivity]
4-(DIFLUOROMETHOXY)ACETOPHENONE is a chemical compound that contains the difluoromethoxy group. It has been shown to be a nitrogen-containing heterocycle, which makes it an important part of many pyridine derivatives. The cyclic molecule is also known as 1,2-difluoroethanone. | [Synthesis]
To a stirred solution of 4-hydroxyacetophenone (5.0 g, 36.76 mmol) in N,N-dimethylformamide (DMF, 50 mL) was added sodium 2-chloro-2,2-difluoroacetate (6.2 g, 40.44 mmol) followed by sodium hydroxide (NaOH, 1.76 g, 44.11 mmol). The reaction mixture was stirred at 100 °C for 14 hours. After completion of the reaction, the mixture was diluted with cold water and the product was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a 20-30% ethyl acetate/hexane solvent mixture to afford the target compound 1-(4-difluoromethoxyphenyl)ethanone (3.5 g, 51.0% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6): δ 8.05-8.01 (m, 2H), 7.59-7.22 (m 3H), 2.50 (s, 3H); LC-MS: m/z 187.0 [M+H]+. | [References]
[1] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 215-216 |
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