| Identification | More | [Name]
(R)-4-Chloro-3-hydroxybutyronitrile | [CAS]
84367-31-7 | [Synonyms]
(R)-(+)-4-CHLORO-3-HYDROXYBUTYRONITRILE
(R)-4-CHLORO-3-HYDROXYBUTYRONITRILE
(R)-4-Cloro-3-Hydroxybutyronitrile
(R)-1-CHLOROPENT-4-YN-2-OL | [EINECS(EC#)]
624-620-1 | [Molecular Formula]
C4H6ClNO | [MDL Number]
MFCD00273362 | [Molecular Weight]
119.55 | [MOL File]
84367-31-7.mol |
| Chemical Properties | Back Directory | [alpha ]
11 º (neat) | [Boiling point ]
110 °C1 mm Hg(lit.)
| [density ]
1.250 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.474(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
clear liquid | [pka]
12.67±0.20(Predicted) | [color ]
Colorless to Light yellow | [Optical Rotation]
[α]25/D +11.0°, neat | [BRN ]
1700586 | [InChI]
InChI=1S/C4H6ClNO/c5-3-4(7)1-2-6/h4,7H,1,3H2/t4-/m1/s1 | [InChIKey]
LHBPNZDUNCZWFL-SCSAIBSYSA-N | [SMILES]
C(#N)C[C@@H](O)CCl | [CAS DataBase Reference]
84367-31-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
10-21 | [HS Code ]
29269090 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to pale yellow liquid | [Uses]
(R)-(+)-4-Chloro-3-hydroxybutyronitrile is a chiral reagent used in asymmetric catalysis in organic synthesis. | [Synthesis]
(1) 19.19g (0.174mol) (R)-(-)-chloroglycerol, 50ml dichloromethane into a 250ml three-necked flask, under the condition of ice bath, 22.74g (0.191oml) dichlorosulfoxide was added slowly dropwise. React for 1h, add 40ml of water, the organic layer was w |
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