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84468-24-6

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84468-24-6 Structure

84468-24-6 Structure
IdentificationMore
[Name]

1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE
[CAS]

84468-24-6
[Synonyms]

1-(5-ISOQUINOLINESULFONYL)PIPERAZINE
1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE
1-(5-ISOQUINOLINYLSULFONYL)PIPERAZINE 2HCL
1-(5-ISOQUINOLINYLSULFONYL)-PIPERAZINE HYDROCHLORIDE
C-1
HA-100
HA-100 DIHYDROCHLORIDE
HA-100 HYDROCHLORIDE
1-(5-isoquinolinylsulfonyl)-piperazin
1-(5-isoquinolinylsulfonyl)piperazine
1-(5-isoquinolinesulfonyl)piperazine hydrochloride
1-[(Isoquinolin-5-yl)sulfonyl]piperazine
IQSP
[Molecular Formula]

C13H17Cl2N3O2S
[MDL Number]

MFCD01310980
[Molecular Weight]

350.26
[MOL File]

84468-24-6.mol
Chemical PropertiesBack Directory
[Appearance]

Pale Yellow Crystalline Solid
[Melting point ]

>240°C (dec.)
[Boiling point ]

497.4±55.0 °C(Predicted)
[density ]

1.332±0.06 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

DMSO, Methanol, Water
[form ]

Off-white lyophilized solid.
[pka]

7.66±0.10(Predicted)
[color ]

Off-White to Pale Yellow
[Usage]

Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases
[InChI]

1S/C13H15N3O2S.2ClH/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13;;/h1-5,10,14H,6-9H2;2*1H
[InChIKey]

ZKQAPKKKTQCVKG-UHFFFAOYSA-N
[SMILES]

[H]Cl.[H]Cl.O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O
[CAS DataBase Reference]

84468-24-6(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
[RTECS ]

TM0862600
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Acute Tox. 4 Oral
Hazard InformationBack Directory
[Chemical Properties]

Pale Yellow Crystalline Solid
[Uses]

Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases
[Definition]

ChEBI: 5-(1-piperazinylsulfonyl)isoquinoline is a member of isoquinolines.
[Biological Activity]

Inhibitor of protein kinase C. Vasodilator.
[IC 50]

PKC: 12 μM (IC50); PKG: 4 μM (IC50); PKA: 8 μM (IC50); MLCK: 240 μM (IC50); PKC: 6.5 μM (Ki); MLCK: 61 μM (Ki)
Spectrum DetailBack Directory
[Spectrum Detail]

1-(5-ISOQUINOLINESULFONYL)PIPERAZINE, DIHYDROCHLORIDE(84468-24-6)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

84468-24-6(sigmaaldrich)
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