| Identification | Back Directory | [Name]
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE | [CAS]
84477-87-2 | [Synonyms]
H-7
H-72HCl
1-(5-Isoquinolylsulfonyl)-2-methylpiperazine
1-(5-isoquinolinesulfonyl)-2-methylpiperazine
Isoquinoline-5-sulfonic 2-methyl-1-piperazide
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
1-(5-isoquinolinylsulfonyl)-2-methyl-piperazin
5-(2-methylpiperazin-1-yl)sulfonylisoquinoline
1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE
5-[(2-methyl-1-piperazinyl)sulfonyl]Isoquinoline
1-(5-isoquinolinylsulfonyl)-2-*methylpiperazine F
Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-
(Isoquinoline-5-yl)(2-methylpiperazine-1-yl) sulfone
1-(5-ISOQUINOLINYLSULFONYL)-2-*METHYLPIP ERAZINE FRE
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide | [Molecular Formula]
C14H17N3O2S | [MDL Number]
MFCD00063403 | [MOL File]
84477-87-2.mol | [Molecular Weight]
291.37 |
| Chemical Properties | Back Directory | [Boiling point ]
495.3±55.0 °C(Predicted) | [density ]
1.277±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
ethanol: 20 mg/mL | [form ]
Solid | [pka]
7.69±0.40(Predicted) | [color ]
White to light yellow | [BRN ]
5482740 |
| Hazard Information | Back Directory | [Uses]
Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1]. | [Definition]
ChEBI: A member of the class of N-sulfonylpiperazines that is 2-methylpiperazine substituted at position 1 by a 5-isoquinolinesulfonyl group. | [Biological Activity]
Protein kinase inhibitor. IC 50 values for inhibition of PKC, PKG, PKA and myosin light chain kinase are 6.0, 5.8, 3.0 and 97.0 μ M respectively. | [IC 50]
PKC: 6 μM (Ki) | [References]
[1] Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41. DOI:10.1021/bi00316a032 |
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