| Identification | Back Directory | [Name]
J-2156 | [CAS]
848647-56-3 | [Synonyms]
J-2156
J 2156,J2156
Benzenepropanamide, α-[[(2S)-4-amino-2-[[(4-methyl-1-naphthalenyl)sulfonyl]amino]-1-oxobutyl]amino]-, (αS)- | [Molecular Formula]
C24H28N4O4S | [MDL Number]
MFCD09832554 | [MOL File]
848647-56-3.mol | [Molecular Weight]
468.57 |
| Hazard Information | Back Directory | [Uses]
J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats[1][2]. | [in vivo]
J-2156 (1-10 mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats[1]. | Animal Model: | Breast cancer-induced bone pain (BCIBP)-rats[1] | | Dosage: | 1, 3, 10?mg/kg | | Administration: | IP; for 3 hours | | Result: | Had anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats.
|
| [storage]
Store at -20°C | [References]
[1] Shenoy PA, et al. The Somatostatin Receptor-4 Agonist J-2156 Alleviates Mechanical Hypersensitivity in a Rat Model of Breast Cancer Induced Bone Pain. Front Pharmacol. 2018 May 15;9:495. DOI:10.3389/fphar.2018.00495
[2] Mia Engstr?m, et al. Superagonism at the Human Somatostatin Receptor Subtype 4. J Pharmacol Exp Ther. 2005 Jan;312(1):332-8. DOI:10.1124/jpet.104.075531 |
|
|