| Identification | Back Directory | [Name]
Tos-PEG6-t-Butyl ester | [CAS]
850090-10-7 | [Synonyms]
Tos-PEG5-C2-Boc
Tos-PEG5-CH2CH2COOtBu
Tos-PEG6-t-Butyl ester
tert-butyl 1-(tosyloxy)-3,6,9,12,15-pentaoxaoctadecan-18-oate
4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
3,6,9,12,15-Pentaoxaoctadecan-18-oic acid,1-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C24H40O10S | [MDL Number]
MFCD22683305 | [MOL File]
850090-10-7.mol | [Molecular Weight]
520.63 |
| Hazard Information | Back Directory | [Description]
Tos-PEG6-t-Butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl/ether; PEGs | [References]
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. |
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