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2028284-73-1

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2028284-73-1 Structure

2028284-73-1 Structure
IdentificationBack Directory
[Name]

Tos-PEG5-CH2CO2H
[CAS]

2028284-73-1
[Synonyms]

Tos-PEG5-CH2CO2H
Tos-PEG4-CH2COOH
Tos-PEG5-CH2COOH
Acetic acid, 2-[2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]ethoxy]-
[Molecular Formula]

C17H26O9S
[MDL Number]

MFCD30458013
[MOL File]

2028284-73-1.mol
[Molecular Weight]

406.45
Chemical PropertiesBack Directory
[Boiling point ]

567.7±50.0 °C(Predicted)
[density ]

1.260±0.06 g/cm3(Predicted)
[pka]

3.39±0.10(Predicted)
Hazard InformationBack Directory
[Description]

Tos-PEG5-CH2CO2H is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
[Uses]

Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6
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