| Identification | Back Directory | [Name]
BI Compound D | [CAS]
851658-10-1 | [Synonyms]
BI Compound D
4-Amino-8-[3-[(3,4-dimethoxyphenethyl)amino]propyl]-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-3H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione | [Molecular Formula]
C32H36N6O6 | [MOL File]
851658-10-1.mol | [Molecular Weight]
600.66 |
| Chemical Properties | Back Directory | [Boiling point ]
853.4±75.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.93±0.19(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
OUN58101, also known as MDK-8101, also known as BI-D, is a RSV L-?protein inhibitor. OUN58101 was first reported in patnet WO 2005042530. This product has no formal name at the moment. | [Uses]
RSV L-protein-IN-1 (compound D) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.021 μM). RSV L-protein-IN-1 inhibits Polymerase (IC50=0.089 μM)，and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-1 shows moderate cytotoxicity (CC50=8.4 μM，HEp-2)，also exhibits activity and lowers virus titers in mouse models of RSV infection[1]. | [References]
[1] Liuzzi M, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005 Oct;79(20):13105-15. DOI:10.1128/JVI.79.20.13105-13115.2005 |
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