| Chemical Properties | Back Directory | [density ]
1.369±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Soluble: = 10 mg/ml | [form ]
Solid | [pka]
11.674±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. Z16078526 activates thermogenic gene expression and mitochondrial activity (uncoupled respiration) in mouse brown adipocytes. Z16078526 also stimulates thermogenesis in the mouse[1]. | [References]
[1] Vergnes L, et al. Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation. J Biol Chem. 2020 Oct 30;295(44):15054-15069. DOI:10.1074/jbc.RA120.013322 |
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