| Identification | Back Directory | [Name]
((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid(WXG00614) | [CAS]
852947-39-8 | [Synonyms]
MB-07344
[14C]-MB07344
((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid
((4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)methyl)phosphonic acid(WXG00614)
Phosphonic acid, P-[[4-[[4-hydroxy-3-(1-methylethyl)phenyl]methyl]-3,5-dimethylphenoxy]methyl]- | [Molecular Formula]
C19H25O5P | [MDL Number]
MFCD18827438 | [MOL File]
852947-39-8.mol | [Molecular Weight]
364.373 |
| Chemical Properties | Back Directory | [Boiling point ]
588.9±60.0 °C(Predicted) | [density ]
1.243±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.33±0.10(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys[1]. | [in vivo]
MB-07344 (0.05 mg/kg; i.v.; 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with Atorvastatin in normal rabbits[1]. | Animal Model: | Normal rabbits[1] | | Dosage: | 0.05 mg/kg | | Administration: | Given i.v., 3 times per week for 3 weeks | | Result: | Combination with atorvastatin further reduced cholesterol. |
| [References]
[1] Ito BR, et al. Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol. 2009 Feb;156(3):454-65. DOI:10.1111/j.1750-3639.2009.00038.x |
|
| Company Name: |
Wuxi AppTec
|
| Tel: |
022-59987777 13552403979 |
| Website: |
www.labnetwork.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|