| Identification | More | [Name]
Quinapril | [CAS]
85441-61-8 | [Synonyms]
2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(3S)-2-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID HYDROCHLORIDE
(3s-(2(r*(r*)),3r*))-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride
ACCUPRIL
ACCUPRIN
ACCUPRO
CI-906
PD-109452-2
QUINAPRIL HCL
QUINAPRIL HYDROCHLORIDE
Asig
Quniapril
S-1,2,3,4CTetrahydro-3-IsoquinolinecarboxylicAcid
3-Isoquinolinecarboxylic acid, 2-(2S)-2-(1S)-1-(ethoxycarbonyl)-3-phenylpropylamino-1-oxopropyl-1,2,3,4-tetrahydro-, (3S)-
3-Isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, (3S)-(9CI)
3-Isoquinolinecarboxylic acid, 2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-, [3S-[2[R*(R*)],3R*]]-
Ectren
Koretic
2-[2-(1-Ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
[3S-[2[R^<*>^ (R^<*>^)]，3R^<*>^]]-2-[2-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1，2，3，4-tetrahydro-3-isoquinolinecarboxylic acid | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C25H30N2O5 | [MDL Number]
MFCD00889215 | [Molecular Weight]
438.52 | [MOL File]
85441-61-8.mol |
| Hazard Information | Back Directory | [Description]
Quinapril is an orally active, non-sulfhydryl ACE inhibitor reportedly useful in the
treatment of essential hypertension. The main claimed advantage of quinapril compared
with other available ACE inhibitors is its side-effect profile. It is also effective in the management of congestive heart failure. | [Originator]
Warner-Lambert (USA) | [Uses]
Antihypertensive; enzyme inhibitor (angiotensin-converting). | [Definition]
ChEBI: Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide. | [Brand name]
Accupril (Pfizer); Quinapril (Lupin); Quinapril (Ranbaxy)
;Accupro. | [Clinical Use]
Angiotensin converting enzyme inhibitor:
Hypertension
Congestive heart failure | [Drug interactions]
Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and
increased risk of renal impairment with NSAIDs;
hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia,
hypotension and renal failure with ARBs and
aliskiren.
Bee venom extract: possible severe anaphylactoid
reactions when used together.
Ciclosporin: increased risk of hyperkalaemia and
nephrotoxicity.
Cytotoxics: increased risk of angioedema with
everolimus.
Diuretics: enhanced hypotensive effect;
hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonism
of hypotensive effect.
Gold: flushing and hypotension with sodium
aurothiomalate.
Lithium: reduced excretion (possibility of enhanced
lithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and
nephrotoxicity. | [Metabolism]
Quniapril is a prodrug which is metabolised in the liver
to its active form, quinaprilat, and to minor inactive
metabolites.
Quinaprilat is eliminated primarily by renal excretion. |
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