| Identification | More | [Name]
TRIS(4-METHOXYPHENYL)PHOSPHINE | [CAS]
855-38-9 | [Synonyms]
LABOTEST-BB LTBB005439
TRI(4-METHOXYPHENYL)PHOSPHINE
TRIS(4-METHOXYPHENYL)PHOSPHINE
TRIS(P-ANISYL)PHOSPHINE
TRIS(P-METHOXYPHENYL)PHOSPHINE
Phosphine, tris(p-methoxyphenyl)-
Phosphorus tri-(p-methoxyphenyl)
Tri(p-methoxyphenyl)phosphine
Trianisylphosphine
Tri-p-anisylphosphine
Tris(2-methoxyphenyl)-phosphine/Tris(4-methoxyphenyl)-phosphine
Tris(p-methoxyphenyl)phosphine,98%
TRIS(4-METHOXYPHENYL)PHOSPHINE (TPAP) | [EINECS(EC#)]
212-723-0 | [Molecular Formula]
C21H21O3P | [MDL Number]
MFCD00014896 | [Molecular Weight]
352.36 | [MOL File]
855-38-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White to pale yellow crystalline powder | [Melting point ]
131-134 °C (lit.) | [Boiling point ]
457.8±40.0 °C(Predicted) | [density ]
1.1352 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Crystalline Powder | [color ]
White to pale yellow | [Water Solubility ]
Insoluble in water. | [Sensitive ]
Air Sensitive | [BRN ]
2815911 | [InChI]
InChI=1S/C21H21O3P/c1-22-16-4-10-19(11-5-16)25(20-12-6-17(23-2)7-13-20)21-14-8-18(24-3)9-15-21/h4-15H,1-3H3 | [InChIKey]
UYUUAUOYLFIRJG-UHFFFAOYSA-N | [SMILES]
P(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1 | [CAS DataBase Reference]
855-38-9(CAS DataBase Reference) | [EPA Substance Registry System]
Phosphine, tris(4-methoxyphenyl)- (855-38-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29319090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to pale yellow crystalline powder | [Uses]
suzuki reaction | [Uses]
Tris(4-methoxyphenyl)phosphine is a useful intermediate employed in organic synthesis and in other chemical processes. | [Application]
Tris(4-methoxyphenyl)phosphine is used as a ligand in organometallic chemistry and homogeneous catalysis.
This compound is suitable for the following reaction types: Buchwald-Hartwig Cross Coupling Reaction, Heck Reaction, Hiyama Coupling, Negishi Coupling, Sonogashira Coupling, Stille Coupling, Suzuki-Miyaura Coupling, and Cross Couplings.
| [reaction suitability]
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand
reaction type: Cross Couplings | [Synthesis]
To a solution of tertiary phosphine oxides 2 (0.4mmol) in CH2Cl2 (2mL) was added oxalyl chloride (0.4mmol) dropwise at room temperature under an argon atmosphere. After 30 minutes, HEH (1mmol) was added to the mixture in one portion, and TEA (3mmol) was added. The mixture was stirred for another 2h at 40°C and then diluted with H2O (10mL). The resulting mixture was extracted with CH2Cl2 repeatedly. The extracts were dried (anhydrous Na2SO4) and evaporated. The crude product was purified by column chromatography on silica gel using ethyl acetate/petroleum ether to afford the pure product Tris(4-methoxyphenyl)phosphine. | [References]
[1] Synthesis, 2011, # 24, p. 4091 - 4098
[2] Tetrahedron Letters, 2015, vol. 56, # 7, p. 918 - 920
[3] Chinese Chemical Letters, 2014, vol. 25, # 1, p. 176 - 178
[4] ChemCatChem, 2017, vol. 9, # 24, p. 4460 - 4464
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 50, p. 15989 - 15992 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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