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858350-62-6

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858350-62-6 Structure

858350-62-6 Structure
IdentificationBack Directory
[Name]

AR 244555
[CAS]

858350-62-6
[Synonyms]

AR 244555
Methanone, [1'-(3-buten-1-yl)-5-chloro-1,2-dihydrospiro[3H-indole-3,4'-piperidin]-1-yl](2,6-difluorophenyl)-
[Molecular Formula]

C23H23ClF2N2O
[MDL Number]

MFCD28138741
[MOL File]

858350-62-6.mol
[Molecular Weight]

416.89
Chemical PropertiesBack Directory
[Boiling point ]

546.0±50.0 °C(Predicted)
[density ]

1.31±0.1 g/cm3(Predicted)
[pka]

9.53±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects[1].
[References]

[1] Tong Zhang, et al. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311. DOI:10.1152/ajpheart.00723.2011
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