| Identification | Back Directory | [Name]
CAY10583 | [CAS]
862891-27-8 | [Synonyms]
CAY10583
CAY10583 Exclusive
IUJTVDNJFPZYBL-UHFFFAOYSA-N
4'-((N-phenylpentanamido)methyl)-[1,1'-biphenyl]-2-carboxylic acid
4'-[[(1-Oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid | [Molecular Formula]
C25H25NO3 | [MDL Number]
MFCD34567252 | [MOL File]
862891-27-8.mol | [Molecular Weight]
387.471 |
| Chemical Properties | Back Directory | [Boiling point ]
562.0±43.0 °C(Predicted) | [density ]
1.177±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.25 mg/ml | [form ]
A crystalline solid | [pka]
3.84±0.36(Predicted) | [color ]
white to beige | [InChI]
InChI=1S/C25H25NO3/c1-2-3-13-24(27)26(21-9-5-4-6-10-21)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)25(28)29/h4-12,14-17H,2-3,13,18H2,1H3,(H,28,29) | [InChIKey]
IUJTVDNJFPZYBL-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC=CC=C1C1=CC=C(CN(C(=O)CCCC)C2=CC=CC=C2)C=C1 |
| Hazard Information | Back Directory | [Uses]
4''-[[(1-oxopentyl)phenylamino]methyl]-[1,1''-biphenyl]-2-carboxylic acid is a BLT2 agonist. | [Definition]
ChEBI:[1,1'-biphenyl]-2-carboxylic acid, 4'-[[(1-oxopentyl)phenylamino]methyl]- is a member of biphenyls. | [Biological Activity]
CAY10583 is a potent and selective full agonist for Leukotriene B4 receptor type 2 (BLT2). CAY10583 promotes wound healing and cell proliferation in cultured intestinal epithelial cells. | [in vivo]
CAY10583 (administered topically to full-thickness wounds; 10 μM; 14 days) significantly results in a greater wound closure than the control group. The difference in wound closure between the CAY-treated group and the control group is pronounced over time until day 10. And the difference is approximately 6% at day 4 and reaches almost 20% at day 8. Notably, 100% closure was observed in the CAY-treated group at day 14[1]. | Animal Model: | Lewis rats (6-9 weeks of age, 180-220 g)[1] | | Dosage: | 10 μM; 14 days | | Administration: | Administered topically to full-thickness wounds; 10 μM; 14 days | | Result: | Accelerated in vivo wound healing by topical application. |
| [IC 50]
BLT2 | [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|