| Identification | Back Directory | [Name]
5-(4-fluorophenyl)-N-(4-methoxybenzo[d]thiazol-2-yl)-1,3,4-oxadiazol-2-amine | [CAS]
862974-22-9 | [Synonyms]
HIF-1/2α-IN-2
2-Benzothiazolamine, N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-4-methoxy-
5-(4-fluorophenyl)-N-(4-methoxybenzo[d]thiazol-2-yl)-1,3,4-oxadiazol-2-amine | [Molecular Formula]
C16H11FN4O2S | [MOL File]
862974-22-9.mol | [Molecular Weight]
342.35 |
| Chemical Properties | Back Directory | [Boiling point ]
512.9±56.0 °C(Predicted) | [density ]
1.456±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.00±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HIF-1/2α-IN-2 is an inhibitor of HIF-1/2α. HIF-1/2α-IN-2 decrease HIF-1/2α levels and induces iron starvation response by targeting Iron Sulfur Cluster Assembly 2 (ISCA2)[1]. | [References]
[1] Green YS, et al. ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. Oncogene. 2022 Sep 12. DOI:10.1038/s41388-022-02460-1 |
|
|