| Identification | Back Directory | [Name]
CAY10498 | [CAS]
863202-33-9 | [Synonyms]
CAY10498
CAY10498,CAY-10498
2-phenyl-amino-N6-endo-norbornyladenine
6-N-(3-bicyclo[2.2.1]heptanyl)-2-N-phenyl-7H-purine-2,6-diamine
9H-Purine-2,6-diamine, N6-(1R,2S,4S)-bicyclo[2.2.1]hept-2-yl-N2-phenyl-, rel- | [Molecular Formula]
C18H20N6 | [MDL Number]
MFCD23160216 | [MOL File]
863202-33-9.mol | [Molecular Weight]
320.39 |
| Chemical Properties | Back Directory | [Boiling point ]
652.0±58.0 °C(Predicted) | [density ]
1.403±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:4): .2 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
10.63±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
A3AR antagonist 3 (compound 21) is a selective A3 adenosine receptor (A3AR) antagonist with a Ki of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors[1]. | [IC 50]
hA3: 37 nM (Ki); hA1AR: 2.22 μM (Ki); hA2AAR: 7.73 μM (Ki) | [storage]
Store at -20°C | [References]
[1] Melissa Perreira, et al. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. 2005 Jul 28;48(15):4910-8. DOI:10.1021/jm050221l |
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BOC Sciences
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