| Identification | Back Directory | [Name]
McMMAE | [CAS]
863971-24-8 | [Synonyms]
McMMAE
Mc-MMAE
Mc MMAE
Maleimidocaproyl-monomethylauristatin E
37: PN: WO2007140371 PAGE: 273 claimed sequence
Mc-MMAE,Inhibitor,Drug-Linker Conjugates for ADC,McMMAE,Microtubule/Tubulin,Mc MMAE,inhibit
L-Valinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl- | [Molecular Formula]
C49H78N6O10 | [MDL Number]
MFCD28167757 | [MOL File]
863971-24-8.mol | [Molecular Weight]
911.18 |
| Chemical Properties | Back Directory | [Boiling point ]
1025.2±65.0 °C(Predicted) | [density ]
1.144±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,unstable in solution, ready to use. | [solubility ]
DMSO: ≥ 51 mg/mL (55.97 mM) | [form ]
Powder | [pka]
13.63±0.46(Predicted) | [color ]
White to light yellow | [InChIKey]
MMUKUGXLBJUPND-AXJCKIDNSA-N |
| Hazard Information | Back Directory | [Uses]
Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a agent-linker conjugate for ADC. | [IC 50]
Auristatin | [References]
[1] Sanderson RJ, et al. In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):843-52. PMID:15701875 |
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