| Chemical Properties | Back Directory | [Boiling point ]
634.7±65.0 °C(Predicted) | [density ]
1.439±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 67 mg/mL (200.09 mM);Ethanol: Insoluble | [pka]
9.70±0.10(Predicted) | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1]. | [Biological Activity]
TP0427736 is a potent ALK5 kinase inhibitor with IC50 of 2.72 nM and IC50 of 836 nM for ALK3. It also inhibits TGF-β1-induced phosphorylation of Smad2/3 in A549 cells with IC50 of 8.68 nM. | [in vitro]
TP0427736 can inhibit Smad2/3 phosphorylation in a concentration-dependent manner with IC50 of 8.68 nM. In outer root sheath cells, it rescued the inhibition of cell proliferation by TGF-β1 and TGF-β2. | [in vivo]
TP0427736 reduces hair follicle length shortening during the transition from anagen to catagen. | [target]
| Target | Value | ALK5
(Cell-free assay) | 2.72 nM |
| [storage]
Store at -20°C | [References]
[1] Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491. DOI:10.1016/j.pharep.2017.01.024 |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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