| Identification | Back Directory | [Name]
CX-3543 | [CAS]
865311-47-3 | [Synonyms]
CX-3543
Quarfloxin
Itarnafloxin
Quarfloxacin
CX-3543/Quarfloxin
Quarfloxin (CX-3543)
CX 3543; QUARFLOXACIN; CX3543; CX-3543
inhibit,CX3543,Inhibitor,Quarfloxin,CX 3543,DNA/RNA Synthesis
2-(4-((R)-1-Methylpyrrolidin-2-yl)butanoyl)-6-(3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazin-3-one
5-Fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide
3H-Benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide, 5-fluoro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)-1-pyrrolidinyl]- | [Molecular Formula]
C35H33FN6O3 | [MDL Number]
MFCD17215197 | [MOL File]
865311-47-3.mol | [Molecular Weight]
604.67 |
| Chemical Properties | Back Directory | [Boiling point ]
845.3±65.0 °C(Predicted) | [density ]
1.44 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
11.46±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1]. | [Definition]
ChEBI: Itarnafloxin is a phenoxazine. | [storage]
Store at -20°C | [References]
[1] Hald ?H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12. DOI:10.1038/s41388-018-0611-7 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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