| Identification | Back Directory | [Name]
IC87201 | [CAS]
866927-10-8 | [Synonyms]
IC87201
IC-87201
(IC87201
IC87201 >=98% (HPLC)
2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
Phenol, 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro- | [Molecular Formula]
C13H10Cl2N4O | [MDL Number]
MFCD28160570 | [MOL File]
866927-10-8.mol | [Molecular Weight]
309.15 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);97.04(Max Conc. mM)
DMSO:29.0(Max Conc. mg/mL);93.81(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.81(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);3.23(Max Conc. mM) | [form ]
A solid | [color ]
Pink to red | [InChI]
InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19) | [InChIKey]
QEHVTUCLCBXQIC-UHFFFAOYSA-N | [SMILES]
C1(O)=C(Cl)C=C(Cl)C=C1CNC1C=C2NN=NC2=CC=1 |
| Hazard Information | Back Directory | [Uses]
IC 87201 (cas# 866927-10-8) is a useful research chemical.IC 87201 is a small molecule inhibitor. It inhibited the in vitro binding of nNOS with PSD95, without inhibiting nNOS catalytic activity. | [Biological Activity]
IC87201 is a potent inhibitor of the nNOS/PSD-95 protein-protein interaction th at blocks NMDA-induced 3μ ,5μ -cyclic guanosine monophosphate (cGMP) production in hippocampal cultures. IC87201 exhibits analgesic properties in mice pain models. Contrary to NMDA receptor antagonists nNOS/PSD-95 protein-protein interaction inhibitors spared source memoryspatial memoryand motor function in rats. | [in vivo]
IC87201 (1, 4 and 10 mg/kg, i.p.) does not produce impairment in either spatial working memory or source memory[2]. IC87201 (1 mg/kg) is effective in treating NMDA-induced thermal hyperalgesia in mice, with a corresponding peak plasma level of 55 ng/mL (or 0.2 μM)[3]. | [IC 50]
NMDA Receptor |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|