| Identification | Back Directory | [Name]
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine | [CAS]
867017-68-3 | [Synonyms]
TC-S 7001
Azaindole 1
Rho Kinase Inhibitors
RHO-KINASE INHIBITOR;RHO KINASE INHIBITOR
RHO-KINASE INHIBITOR; RHO KINASE INHIBITOR; ROCK
6-CHLORO-N4-[3,5-DIFLUORO-4-[(3-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-4-YL)OXY]PHENYL]PYRIMIDIN-2,4-DIAMINE
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
2,4-Pyrimidinediamine, 6-chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]- | [Molecular Formula]
C18H13ClF2N6O | [MDL Number]
MFCD15528941 | [MOL File]
867017-68-3.mol | [Molecular Weight]
402.79 |
| Chemical Properties | Back Directory | [density ]
1.61 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO: Soluble; Ethanol: Soluble | [form ]
A solid | [pka]
13.56±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TC-S 7001 is a novel potent and highly selective azaindole-based inhibitor of Rho-kinase (ROCK). It exhibits long-acting vasodilator activity and decreases pulmonary and systemic arterial pressure in rats. | [in vivo]
BAY-549 (Azaindole 1) (0.03, 0.1, 0.3 mg/kg, i.v.) results in a dose-dependent and long-lasting decrease in blood pressure in anaesthetized normotensive rats. BAY-549 (3 and 10 mg/kg, p.o.) decreases blood pressure dose-dependently and persistently both in normotensive and hypertensive rats, and shows such effects even at 1 mg/kg in hypertensive rats. BAY-549 (0.1 and 0.3 mg/kg, i.v. bolus injections) causes decreased mean arterial blood pressure in a dose-related manner and only leads to a moderate and dose-independent increase in heart rate of anaesthetized dogs[1]. | [IC 50]
ROCK-1: 0.6 nM (IC50); ROCK-2: 1.1 nM (IC50); TRK: 252 nM (IC50); FLT3: 303 nM (IC50) | [storage]
Store at -20°C |
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