| Identification | Back Directory | [Name]
Benzoic acid, 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-, sodium salt (1:1) | [CAS]
869366-15-4 | [Synonyms]
MLN8054 sodium
Benzoic acid, 4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-, sodium salt (1:1) | [Molecular Formula]
C25H16ClF2N4NaO2 | [MOL File]
869366-15-4.mol | [Molecular Weight]
500.87 |
| Hazard Information | Back Directory | [Uses]
MLN8054 sodium is an Aurora A inhibitor with radiosensitivity-enhancing activity. MLN8054 sodium can activate the DNA double-strand break reaction of prostate cancer cells in in vitro experiments. The application of MLN8054 sodium is closely related to accumulation in the G2/M phase of the cell cycle and polyploid formation. In vivo experiments show that MLN8054 sodium can significantly delay the growth of prostate cancer tumors and promote tumor cell apoptosis when used in combination with radiotherapy[1]. | [References]
[1] Manfredi MG, et al. Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4106-11. DOI:10.1073/pnas.0608798104
[2] Huck JJ, et al. MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. Mol Cancer Res. 2010 Mar;8(3):373-84. DOI:10.1158/1541-7786.MCR-09-0300
[3] MLN8054, a small molecule inhibitor of aurora kinase a, sensitizes androgen-resistant prostate cancer to radiation DOI:10.1016/j.ijrobp.2011.01.060 |
|
|