870487-48-2

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870487-48-2 Structure

Identification	Back Directory
[Name] Mes-PEG5- t-butyl ester
[CAS] 870487-48-2
[Synonyms] CAS_870487-48-2 MS-PEG5- t-butyl ester Mes-PEG4-t-butyl ester Mes-PEG5- t-butyl ester
[Molecular Formula] C16H32O9S
[MDL Number] MFCD20926382
[MOL File] 870487-48-2.mol
[Molecular Weight] 400.48

Hazard Information	Back Directory
[Description] Ms-PEG4-t-butyl ester is a PEG linker with a mesyl group and a t-butyl protecting group. Mesyl is a good leaving group and can participate in substitution reactions. The t-butyl group can be removed under acidic condtions. The hydrophilic PEG linker increases the solubility properties of compounds in aqueous media.
[Uses] Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50] PEGs; Alkyl/ether
[References] [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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